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Experimental studies in PD models have reported that activation of the 5-HT 2A receptor by serotonin upregulates mitochondrial biogenesis and ATP production in cortical neurons via Sirt1 and PGC-1α (Guo et al., 2016), while a small molecule Sirt1 agonist has been found to protect neurons from cell death in a PD animal model ((Lofrumento et al., 2014)

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The results showed that robust GPX1 labeling was observed in cochlear SGNs of P3, P14, and P30 mice, and it appeared that the expression of GPX1 was mainly in the cytoplasm but not in the nuclei of SGNs (Figure 1B)